Mario de Lucio's website

I am a Post Doctoral Scientist at Eli Lilly and Company working in Drug Delivery and New Product Innovation (DDNPI) within Delivery, Devices and Connected Solutions (DDCS).

I consider myself a computational mechanician, I develop new modeling and computer-based simulation techniques to address real-world problems in mechanical and biomedical engineering. The core of my research philosophy lies in bridging the gap between computational theory and practical application. I am interested in tailoring computational models to capture the complex dynamics occurring at the intersection between biology and mechanics, providing insights that are not easily attainable through experimental methods alone.

In my PhD thesis, I focused on the transport and mechanical processes behind subcutaneous injection for self-administration of biotherapeutics, particularly monoclonal antibodies (mAbs). My research developed a high-fidelity computational framework to study large-volume subcutaneous injection of mAbs, combining large-deformation mechanics, and porous media flow with drug transport and absorption. My simulations provided essential insights into improving subcutaneous drug administration and developing patient-centered injection devices and techniques.

news

Apr 24, 2025	We just released AneuPy
Feb 27, 2025	Mario de Lucio participates as an actor in the Purdue University Enterprise Campaign
Dec 12, 2024	Our paper on a MPET2-mPBPK model for subcutaneous injection of biotherapeutics with different molecular weights has been published in Computer Methods and Programs in Biomedicine.
Oct 21, 2024	Mario de Lucio is selected as a 2024 Robert J. Melosh Medal Finalist
Oct 07, 2024	Our Research on mAb Transport Featured by the Pittsburgh Supercomputing Center
Jul 10, 2024	Our paper on modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies just got published in the International Journal of Pharmaceutics
Apr 03, 2024	Mario succesfully defended his PhD thesis
Nov 10, 2023	Mario is awarded the Ben M. Hillberry Graduate Scholarship
Jul 22, 2023	Mario de Lucio is selected as a 2023 Trailblazers in Engineering Fellow by Purdue College of Engineering.
Jul 03, 2023	Mario de Lucio wins the Runner-up award in the Poromechanics student competition at the Engineering Mechanics Institute Conference in Atlanta, GA.

Selected publications

AneuPy: An open source Python tool for creating simulation-ready geometries of abdominal aortic aneurysms

Mario de Lucio, Jacobo Diaz, Alberto Castro, and Luis E. Romera

arXiv, physics.med-ph, 2025

Abs Bib

Abdominal aortic aneurysms (AAAs) are localized dilations of the abdominal aorta that can lead to life-threatening rupture if left untreated. AAAs predominantly affect older individuals, with a high mortality rate upon rupture, making early diagnosis and risk assessment critical. The geometric characteristics of an AAA, such as its maximum diameter, asymmetry, and wall thickness, play a crucial role in biomechanical models used to assess rupture risk. Despite the growing use of computational modeling to study AAAs, there is a lack of open source software that facilitates the generation of simulation-ready geometries tailored for biomechanical and hemodynamic analyses. To address this need, we introduce AneuPy, an open-source Python-based tool designed to generate idealized and patient-specific AAA geometrical models. AneuPy provides an efficient and automated approach to aneurysm geometry generation, requiring minimal input data while allowing for flexible parameterization. By streamlining the creation of simulation-ready geometries for finite element analysis (FEA), computational fluid dynamics (CFD), or fluid-structure interaction (FSI) models, AneuPy aims to facilitate research in AAAs and enhance patient-specific risk assessment.
@article{delucio2025aneupyopensourcepython, title = {AneuPy: An open source Python tool for creating simulation-ready geometries of abdominal aortic aneurysms}, journal = {arXiv, physics.med-ph}, author = {{de Lucio}, Mario and Diaz, Jacobo and de Castro, Alberto and Romera, Luis E.}, year = {2025}, doi = {10.48550/arXiv.2504.15285}, url = {https://arxiv.org/abs/2504.15285} }